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Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism
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A phase 2 clinical trial has demonstrated that bimagrumab, when combined with semaglutide, resulted in significant weight loss for trial participants while maintaining lean muscle mass – suggesting a promising approach for
21.03
Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism
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Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial
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New phase 2 data just published in Nature Medicine on bimagrumab combined with semaglutide. Swipe for the breakdown. Follow @adam_nessim for more. Source: Heymsfield et al., Nature Medicine, March 2, 2026
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Bimagrumab preserves lean mass and sustains fat loss during semaglutide-induced weight reduction in diet-induced obese mice
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This New Drug Combo Beats GLP-1s Alone, Without One of the Biggest Side Effects
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