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Five drugs are now approved by the US FDA for long term weight management in adults: orlistat, phentermine topiramate, naltrexone bupropion extended release, liraglutide, and semaglutide. However less than 1% of US adults with obesity FDA: Eli Lilly weight loss drug Zepbound no longer in shortage Novo Nordisk Files NDA For Chronic Weight Management Drug Managed Healthcare Executive And here it is, the long awaited top story from 2024. Thanks for following our countdown to No. 1! Since the 2017 FDA approval of semaglutide to treat type 2 diabetes and obesity, GLP 1 medications like semaglutide (Ozempic) and tirzepatide (Mounjaro) have traditionally been used to treat diabetes. They work by mimicking a natural hormone called GLP 1, which helps regulate blood sugar levels and appetite.